We understand that families rely on us and we continue to work hard to get our infant formulas on shelves as quickly as possible. Please visit the Similac® Information Centre for product availability updates.

Breast milk is best for your baby.

Health Canada, the Canadian Paediatric Society, and the Dietitians of Canada recommend that you exclusively breastfeed your baby for the first 6 months and that you continue to breastfeed for up to 2 years or longer along with complementary foods.

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Home / Products / Similac Pro-Advance® Step 2

Similac Pro-Advance® Step 2, breast milk-inspired

Discover our closest formula to breast milk: Similac Pro-Advance® Step 2

2’-FL is a unique component of breast milk that helps build baby’s immune system. Parents who fed their babies Similac® with 2’-FL reported 3 TIMES FEWER respiratory infections.1,2§

This calcium-enriched, non-GMO* formula also contains an exclusive blend of DHA, lutein and natural vitamin E††, making it our most advanced and closest formula to breast milk.

With Similac Pro-Advance®, you can trust that you are giving your baby the nutrients they need to grow.

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Introducing Similac Pro-Advance®. The first baby formula with 2’FL. 2’-FL in breast milk helps build baby’s immune system. A breakthrough in immune support innovation. Inspired by 20 years of research, from Similac®.

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BREAST MILK-INSPIRED: 2'-FL

Breast milk contains protective immune factors, including human milk oligosaccharides (HMOs) such as 2'-FL, that help build baby’s developing immune system.1

HMOs are non-digestible carbohydrates that form the third most abundant solid component of breast milk.2,3

About 70% of the immune system is found in the gut, so maintaining a favourable environment for good bacteria to develop can help babies build strong digestive and immune systems.2,4

HMOs, like 2'-FL, in breast milk, may support the breastfed baby's immune system in various ways:2

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  • 2’-FL feeds good bacteria in the baby’s gut

    Feed the good bacteria
    in baby’s gut
    (prebiotics)

  • 2’FL protects against harmful bacteria in the baby’s gut

    Protect against
    harmful bacteria
    in the gut

  • 2’FL supports the baby’s developing immune system

    Support baby’s
    developing immune
    system

Nutrition beyond DHA

Because the first year of life is a critical time for your baby’s brain and eye development.

  • This Similac® formula has DHA, an omega-3 fat for brain development

    Naturally found in breast milk, DHA, an Omega-3 fat, supports the normal physical development of the baby’s brain and eyes.

    DHA is prone to damage from oxidation. Breast milk contains antioxidants such as lutein and vitamin E to help protect fats in body tissues from oxidation.5,6

    When you start offering foods, your baby will get DHA from fatty fish such as salmon, sardines and tuna, as well as Omega-3 eggs.

  • This Similac® baby formula contains lutein for brain & eye development

    Lutein is an antioxidant found in breast milk and is concentrated in the baby’s brain and eyes.7,8 Similac Pro-Advance® Step 2 contains added lutein.

    Lutein comes from solid foods like leafy greens, corn and eggs.9 Until you start offering solid foods, your baby can get lutein from breast milk or Similac® formulas with added lutein, such as Similac Pro-Advance® Step 2.

  • This Similac® infant formula contains the antioxidant

    Vitamin E is an antioxidant found in breast milk, but not all vitamin E is the same. One of the great things about Similac Pro-Advance® Step 2 is that it uses natural vitamin E.†† This is the most abundant type found in breast milk and the infant brain.10,11

    You can only get natural vitamin E†† from foods. Rich food sources include dark leafy greens, eggs, fish, nuts and seeds.

  •   Not derived from human milk.
  •   Breast milk contains many immune components.
  • §   Compared to babies fed an infant formula without 2'-FL. Post-hoc analysis of parent-reported, doctor assessed adverse events.
  • *   Ingredients not genetically engineered.
  • ††    RRR-alpha-tocopherol, the most bioactive form of vitamin E.

1. Boix-Amorós A, et al. Nutr Rev. 2019;77(8):541–556. 2. Jantscher-Krenn E, Bode L. Minerva Pediatr . 2012;64:83–99. 3. Zivkovic AM, et al. Proc Natl Acad Sci. 2011;108(Suppl. 1):4653-8. 4. Holmgren J, et al. Immunobiology. 1992;184(2–3): 157-179. 5. Monaco MH, et al. Human Milk: Composition and Nutritional Value. In: Caballero B, Finglas PM, Toldrá F, eds. Encyclopedia of Food and Health, Academic Press, 2016:357-362. 6. Harris M. Vitam Trace Elem 2013;2(2):1-2. 7. Krinsky NI, et al. Ann Rev Nutr. 2003;23:171-201. 8. Vishwanathan R, et al. J Pediatr Gastroenterol Nutr. 2014;59(5);659-665. 9. Sommerburg O, et al. Br J Ophthalmol. 1998;82:907-910.
10. Kuchan MJ, et al. Br J Nutr. 2016;116:126-131. 11. Kuchan MJ, et al. Curr Dev Nutr. 2018;2(8).

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How to prepare and store baby formula

Refer to label for most accurate information. Nutritional composition and ingredients may vary slightly between formats.

POWDER
Per 100 mL at standard dilution

  • Energy (Cal)68
  • Protein (g)1.4
  • Taurine (mg)4.5
  • Carnitine (mg)0.99
  • Tryptophan (mg)24
  • Fat (g)3.7
    • Linoleic Acid (g)0.53
    • Linolenic Acid (g)0.05
    • Arachidonic Acid (ARA) (g)0.014
    • Docosahexaenoic Acid (DHA) (g)0.0072
  • Carbohydrate (g)7.3
    • Fibre (g)0.18
    • 2’-fucosyllactose (2’-FL) (mg)20
  • Inositol (mg)4
  • Lutein (mg)0.0076

(per 100 mL standard dilution)

  • Vitamin A (IU)190
  • Vitamin D (IU)40
  • Vitamin E (IU)2.7
  • Vitamin K (mg)0.009
  • Vitamin C (mg)10
  • Thiamine (mg)0.08
  • Riboflavin (mg)0.11
  • Niacin (mg)0.72
  • Vitamin B6 (mg)0.041
  • Folic Acid (mg)0.0069
  • Vitamin B12 (mg)0.00017
  • Pantothenic Acid (mg)0.3
  • Biotin (mg)0.0025
  • Choline (mg)10
  • Sodium (mg)18
  • Potassium (mg)80
  • Chloride (mg)44
  • Calcium (mg)80
  • Phosphorus (mg)40
  • Magnesium (mg)5.2
  • Iron (mg)1.2
  • Zinc (mg)0.50
  • Copper (mg)0.053
  • Manganese (mg)0.0048
  • Iodine (mg)0.013
  • Selenium (mg)0.0013
  • Ash (g)0.38
  • Nucleotides (mg)7.2
INGREDIENTS

Lactose, Dry or evaporated skim milk, High oleic safflower oil, Whey protein concentrate, Soy oil, Coconut oil, Fructooligosaccharides, Whey protein hydrolysate, M. alpina oil (a source of ARA), 2’-fucosyllactose (2’-FL), Schizochytrium sp. oil (a source of DHA), Soy lecithin, L-tryptophan, Taurine, M-inositol, Cytidine 5’-monophosphate, Ascorbyl palmitate, Disodium guanosine 5ʹ-monophosphate, Disodium uridine 5’-monophosphate, Adenosine 5’-monophosphate, Mixed tocopherols, L-carnitine, Lutein, Minerals (tricalcium phosphate, calcium carbonate, potassium citrate, potassium hydroxide, magnesium chloride, sodium chloride, ferrous sulphate, zinc sulphate, copper sulphate, manganese sulphate, potassium iodide, sodium selenite), Vitamins (ascorbic acid, choline bitartrate, D-alpha-tocopheryl acetate, niacinamide, calcium D-pantothenate, vitamin A palmitate, thiamine chloride hydrochloride, riboflavin, pyridoxine hydrochloride, folic acid, beta-carotene, phylloquinone, vitamin D3, D-biotin, cyanocobalamin). Contains: Milk, Soy. Not for infants/children with galactosemia.

Refer to label for most accurate information. Nutritional composition and ingredients may vary slightly between formats.

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Membership benefits

† Offer received may vary depending on your location and baby's date of birth.

MORE PRODUCTS FOR OLDER BABIES & TODDLERS (6-24 MONTHS)

  • Similac Advance Step 2

    Similac® Advance® Step 2

    Specially designed for growing babies and toddlers 6-24 months, this calcium-enriched formula is non-GMO* and easy-to-digest, and has an exclusive blend of DHA, lutein and vitamin E.

    • * Ingredients not genetically engineered.
    • † Similar to other infant formulas.
  • Similac Step 2

    Similac® Step 2

    A calcium-enriched formula specially designed to support growing babies and toddlers 6-24 months of age.

  • Similac Go & Grow milk powder formula for toddler growth and development

    GO & GROW BY SIMILAC STEP 3

    An everyday drink designed for toddlers 12-36 months with 2’-FL, the most abundant oligosaccharide in breast milk.1 It is non-GMO* and has an exclusive blend of DHA, lutein and vitamin E.

    • † Not derived from human milk.
    • * Ingredients not genetically engineered.
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QUESTIONS AND ANSWERS

  • How to prepare baby formula?

    Refer to the product label for complete preparation instructions.


    Your baby’s health depends on carefully following these directions. Wash hands thoroughly with soap and water. Proper hygiene, preparation, mixing and storage are important when using infant formula. Use as directed by your health care professional.


    WARNING: Powdered infant formulas are not sterile and should not be fed to preterm, low birth-weight or immunocompromised infants unless directed and supervised by a health care professional. Never use a microwave oven to warm formula; serious burns can result. Test temperature before feeding to avoid scalding the baby’s mouth.


    Directions for preparation and use of powder baby formula – Must add water


    1. Wash hands thoroughly with soap and water.
    2. Sterilize equipment:
      • Place washed bottles, nipples, rings, caps, and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
      Sterilize water:
      • In another pot, boil water at a rolling boil for 2 minutes. Cool to room temperature.
    3. Prepare formula using enclosed scoop – See MIXING GUIDE on label. Return dry scoop to container.
    4. Cap bottle; shake well; attach nipple. Once feeding begins, use within 1 hour or discard.

    Storage: Once mixed, refrigerate bottles immediately; use within 24 hours. Store powder formula container under normal room temperature conditions. Once opened, use contents within 1 month. Do not reuse container.


    Directions for preparation and use of concentrated liquid formula – Must add water


    Must add equal amounts of water (boiled and cooled to room temperature) and concentrated liquid formula.

    1. Wash hands thoroughly with soap and water.
    2. Sterilize equipment:
      • Place washed bottles, nipples, rings, caps and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes. 
      Sterilize water for formula:
      • In another pot, bring water to a rolling boil for 2 minutes. Cool to room temperature.
    3. Prepare formula – Must add water
      • Clean top of can. Shake well before opening.
      • Pour equal amounts of concentrated liquid formula and cooled sterilized water into bottle – See MIXING GUIDE on label.
    4. Cap bottle; shake well; attach nipple. Once feeding begins, use within 1 hour or discard.

    Storage: Cover prepared bottles and opened cans and refrigerate immediately; use within 48 hours. Store unopened cans under normal room temperature conditions. Avoid extreme temperatures.


    Directions for preparation and use of ready-to-use formula - Do not add water


    59-mL plastic bottles:

    1. Wash hands thoroughly with soap and water.
    2. Place washed nipple, ring and cap in boiling water and keep at a rolling boil for 2 minutes.
    3. SHAKE BOTTLE WELL before opening and twist-off cap.
    4. Attach nipple. Once feeding begins, use within 1 hour or discard.

    235-mL plastic bottles:

    1. Wash hands thoroughly with soap and water.
    2. Sterilize equipment: Place washed cups or bottles (if needed), nipples, rings, caps and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
    3. Shake bottle well; twist off cap.
    4. If using the Similac® bottle: Attach nipple. If using a different feeding container: Pour formula into cups or bottles. If there is formula remaining in the Similac® bottle, recap, refrigerate and use within 48 hours.
    5. Once feeding begins, use within 1 hour or discard.

    Cans:

    1. Place washed bottles, nipples, rings, caps, and all preparation equipment in boiling water and keep at a rolling boil for 2 minutes.
    2. Clean top of can. Shake well before opening. Pour formula into bottle; attach nipple.

    Storage: Cover prepared bottles/cups and opened bottles/cans and refrigerate immediately; use within 48 hours. Store unopened bottles/cans under normal room temperature conditions. Avoid extreme temperatures. Do not reuse the Similac® bottle.